Phloridzin Pure

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•Product name: Phloridzin 95.0%
•Also known as: Phlorizin dihydrate, Apple peel extract, Apple Polyphenols, Phloretin
•Product code: YG-SWA004
•Botanical source: Malus pumila Mill.
•Phloridzin CAS No.: 60-81-1
•Molecular Formula: C21H24O10
•Certifications: ISO, HACCP, CQC, KOSHER, HALAL
•Specification: 95.0% Phloridzin
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Product Details

Product Instruction

◆ Phloridzin pure is the specific and competitive inhibition of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). This property which could be useful in the management of postprandial hyperglycemia in diabetes and related disorders.

◆ Phloridzin is one of the dihydrochalcones typically contained in apples and in apple-derived products. The effect of phloridzin orally doses 5, 10, 20 and 40 mg/kg body weight on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1. From beneficial effect of this compound is significant reduction of blood glucose levels and improve dyslipidemia in diabetic rats. As a well-known consequence of becoming diabetic, urine volume and water intake were significantly increased.

◆ Administration of phloridzin reduced urine volume and water intake in a dose-dependent manner. Phloretin decreases of food consumption, as well as a marked lowering in the weight. In conclusion, this compound could be proposed as an antihyperglycemic and antihyperlipidemic agent in diabetes and potential therapeutic in obesity.

 

Specification of Phloridzin 95.0%

ITEMS

SPECIFICATIONS

METHOD/STANDARD

Characters

Powder

Organoleptic

Color

Light yellow to white

Organoleptic 

Odor

Characteristic

Organoleptic

Mesh

80

Mesh 80

Solubility

Soluble in   ethanol

In-House

Loss on drying

≤0.3%

5g/100℃/2.5hrs

Residue on ignition

≤0.10%

--

Chloride

≤0.05%

--

Sulfate

≤0.03%

--

Iron

≤30ppm

--

Identification:


By HPLC/TLC

Assay

90.0%~99.5% 

HPLC

Heavy Metals

≤10ppm

CP2010

Pb   

≤1ppm

CP2010

As

≤2ppm

CP2010

Hg

≤0.1ppm

CP2010

Cd

≤1.0ppm 

CP2010

Microbiological



Total Plate Count

1000cfu/g Max

CP2010

Yeast&Mold

100cfu/g Max

CP2010

E.Coli colonies/g

Negative (-)

CP2010

Samonella colonies/g

Negative (-)

CP2010


Product benefits

◆ Phloridzin pure can be used to treat diabetes. It can inhibit the renal proximal tubule reabsorption of glucose, urinary glucose excretion increased, thereby reducing the level of blood glucose and serum insulin levels are not affected.

◆ Phloridzin can be used to whitening and acne treatment. Phlorizin can prevent the entry of glucose into epidermal cells, thereby slowing the secretion of sebum to help prevent the occurrence of acne. Tyrosinase is the major rate-limiting enzyme of the melanin biosynthesis, phlorizin through to inhibit tyrosinase to achieve whitening.

◆ Reduce the number of atherosclerotic lesions in arteries, the amount of cholesterol produced in the liver and uric acid content in the blood.

◆ Slow the growth of cancer cells and tumors and promote cancer cell death. Prevent skin, breast and colon cancer, and lower the risk of colon and lung cancer; Effect against external aging by promoting the health of skin cells and rejuvenation. ◆ Effect the Internal aging by promoting organ health, destroying the free radicals and strengthening fibers.

 

Product application

◆ Phloridzin pure be used in skin care product.

◆ Apple fruit extract can be used in nutrition food and supplements.

◆ For functional food, apple fruit extract used as capsules or pills.

◆ Widely used in pharmaceutical field as medicine raw material.

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