◆ Phloridzin pure is the specific and competitive inhibition of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). This property which could be useful in the management of postprandial hyperglycemia in diabetes and related disorders.
◆ Phloridzin is one of the dihydrochalcones typically contained in apples and in apple-derived products. The effect of phloridzin orally doses 5, 10, 20 and 40 mg/kg body weight on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1. From beneficial effect of this compound is significant reduction of blood glucose levels and improve dyslipidemia in diabetic rats. As a well-known consequence of becoming diabetic, urine volume and water intake were significantly increased.
◆ Administration of phloridzin reduced urine volume and water intake in a dose-dependent manner. Phloretin decreases of food consumption, as well as a marked lowering in the weight. In conclusion, this compound could be proposed as an antihyperglycemic and antihyperlipidemic agent in diabetes and potential therapeutic in obesity.
Specification of Phloridzin 95.0%
Light yellow to white
Soluble in ethanol
Loss on drying
Residue on ignition
Total Plate Count
◆ Phloridzin pure can be used to treat diabetes. It can inhibit the renal proximal tubule reabsorption of glucose, urinary glucose excretion increased, thereby reducing the level of blood glucose and serum insulin levels are not affected.
◆ Phloridzin can be used to whitening and acne treatment. Phlorizin can prevent the entry of glucose into epidermal cells, thereby slowing the secretion of sebum to help prevent the occurrence of acne. Tyrosinase is the major rate-limiting enzyme of the melanin biosynthesis, phlorizin through to inhibit tyrosinase to achieve whitening.
◆ Reduce the number of atherosclerotic lesions in arteries, the amount of cholesterol produced in the liver and uric acid content in the blood.
◆ Slow the growth of cancer cells and tumors and promote cancer cell death. Prevent skin, breast and colon cancer, and lower the risk of colon and lung cancer; Effect against external aging by promoting the health of skin cells and rejuvenation. ◆ Effect the Internal aging by promoting organ health, destroying the free radicals and strengthening fibers.
◆ Phloridzin pure be used in skin care product.
◆ Apple fruit extract can be used in nutrition food and supplements.
◆ For functional food, apple fruit extract used as capsules or pills.
◆ Widely used in pharmaceutical field as medicine raw material.