Genistein Extract

Genistein Extract

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•Product name: Genistein 98.0%
•Also known as: 4',5,7-trihydroxyisoflavone, genisteol, genisterin, prunetol, sophoricol
•Product code: YG-BLA017
•Botanical source: Glycine mao(L). Merr.
•Genistein CAS No.: 446-72-0
•Formula: C15H10O5
•Active ingredient: Genistein
•Certifications: ISO, HACCP, CQC, KOSHER, HALAL
•Specification: Genistein 98.0%HPLC
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Product Details

Genistein Extract Instruction

◆ Genistein, a kind of phytoestrogen, is an isoflavone compound extracted from Sophora japonica, a natural tyrosine kinase whose chemical structure is similar to endogenous estrogen It is reported that it can combine with estrogen membrane and intracellular receptors to play a role, such as anti-tumor effect, neuroprotective effect, regulation of bone metabolism and lipid metabolism, anti-liver fibrosis, cardiovascular protection and anti-oxidation.  

◆ This powder can achieve the protective effect on nerve damage caused by various factors by directly binding to Aβ, anti-oxidation, inhibiting Ca2 + overload, reducing the toxicity of glutamate, reducing the expression of pro-inflammatory cytokines, and regulating signal transduction pathways.

 

Specification of Genistein 98.0%HPLC

ITEMS

SPECIFICATIONS

METHOD/STANDARD

Characters

Powder

Organoleptic

Color

Yellow white

Organoleptic

Solubility

Soluble Ethanol

--

Loss on drying

≤2.0%

--

Melting point

297℃ - 298℃

--

Solvent Residue

Eur.Pharm

--

Pesticide Residue

Negative

--

Identification:


By HPLC/TLC/IR

Assay (On dry basis)

≥98.0% Genistein

HPLC

Heavy Metals

≤10.0ppm

ASS

Pb   

≤1.0ppm

ASS

As

≤1.0ppm

ASS

Hg

≤0.1ppm

ASS

Cd

≤0.2ppm 

ASS

Microbiological



Total Plate Count

1000cfu/g Max

AOAC990.12,16th

Yeast&Mold

100cfu/g Max

AOAC996.08,   991.14

E.Coli colonies/g

Negative (-)

AOAC2001.05

Samonella colonies/g

Negative (-)

AOAC990.12


 Genistein Extract Benefits

◆ Soybean extract can bind to estrogen receptors, play a weak estrogen-like effects,increaes bone density , and prevent bone loss, to treat osteoporosis.

◆ It also has certain anticancer effect, can kill various cancer cells without damaging the normal cells.

◆ Genistein extract powder have anti-peroxidation activity, can increase the activity of lower density lipoprotein receptor, reduce cholesterol levels, accelerated cholesterol removal, to reduce plasma lipid and anti-thrombosis.

◆ 4,5,7-Trihydroxyisoflavone can inhibit mouse fibroblast NIH3T3 cell proliferation and collagen synthesis in vitro, it has therapeutic potential against liver fibrosis by regulating PDGF and TGFß1.

 

Genistein Extract Application

◆ Applied in food field, it is added into kinds of beverage, liquor and foods as functional food additive.

◆ Applied in health product field, it is widely added into various kinds of health products to prevent chronic diseases or relief symptom of climacteric syndrome.

◆ Applied in cosmetics field, it is widely added into the cosmetics with the function of delaying aging and compacting skin, thus make skin much smooth and delicate.

 

Safety Concerns

◆ Many of the often-cited genotoxic effects, including apoptosis, cell growth inhibition, topoisomerase inhibition and others become less obvious. Recent cellular, epigenetic and microarray studies are beginning to decipher effects that occur at dietarily relevant low concentrations. 

◆ In toxicology, the well accepted principle of "the dose defines the poison" applies to many toxicants and can be invoked, as herein, to distinguish genotoxic versus potentially beneficial in vitro effects of natural dietary products. 

 

Dosage Information

◆ In consideration of levels of dietary 4,5,7-Trihydroxyisoflavone uptake and bioavailability. we have defined in vitro concentrations of genistein >5 microM as non-physiological, and thus "high" doses.

 

Therapeutic Dosages

◆ The optimum dosage is unknown. In Asia, population groups who eat soy foods daily containing 20 mg to 80 mg of this product have lower rates of breast and prostate cancer than do groups in the West with less this powder in their diets. However, we don't know whether genistein (or even soy isoflavones generally) are responsible for this effect.

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