Gallic Acid Instruction
◆ Gallic acid (GA), also known as pyrogallol-5-carboxylic acid, is a natural product chemical component, chemically named 3,4,5-trihydroxybenzoic acid, which has high medicinal value. It is widely present in plants such as palm leaf rhubarb, Eucalyptus grandis, dogwood, dried celandine, horse mulberry, fragrant tree, tallow tree, pomegranate, yellow grass, acacia, etc. It is a polyphenolic compound present in nature. Gallic acid, also known as gallic acid and times acid, chemical name 3,4,5-trihydroxybenzoic acid (C H O), is white or light yellow needle crystal or powder, usually in the form of monohydrate.
◆ Gallnut is a special product of China's forest. The hydrolyzed tannin contained in it can be hydrolyzed under the action of acid, alkali and enzyme to produce gallic acid. It is a natural polyphenolic substance with various biological activities such as anti-oxidation, bacteriostasis and anti-caries, and is widely used in medicine, food and other fields
◆ The chemical name of pyrogallol-5-carboxylic acid is 3,4,5-trihydroxybenzoic acid, the molecular formula is C7H6O5, and the molecular weight is 170.12. It usually exists in the form of monohydrate, which is white or yellowish needle crystals at room temperature ℃) Slightly soluble in water, easily soluble in boiling water, ether, acetone, etc., insoluble in organic solvents such as chloroform and benzene. Gallic acid has strong reducing properties, turns brown in case of oxygen in the air, and can also be combined with proteins, gels, heavy metals, alkaloids, etc.
Specification of Gallic Acid (monohydrate) 99.0%
A white to beige powder
Loss on drying
Solubility (Turbidity) 50mg/ml ETOH
Residue on Ignition
Impurity of aromatic compounds
◆ Studies have shown that gallic acid anhydrous inhibits toxic effects of arsenic on the spleen, heart and blood of rats by reducing oxidative stress, and can significantly reduce arsenic-induced malondialdehyde (MDA) and monoxide in rat heart and spleen The nitrogen content increases the activity of glutathione peroxidase and superoxide dismutase (SOD) and reduces the activity of creatine kinase in rat serum induced by arsenic.
◆It can inhibit the growth of human nasopharyngeal carcinoma CNE-2 cell line tumor-bearing transplanted nude mice, and promotes tumor cell apoptosis in a certain concentration range with a positive correlation with concentration. Its mechanism of action is that gallic acid promotes the release of cytochrome c from mitochondria in tumor cells, which in turn activates caspase-9, caspase-3 and the DNA repair enzyme polyadenosine diphosphate ribose polymerase. By regulating the caspase pathway to promote tumor cell apoptosis.
◆ Galla chinensis extract momohydrate can cause streptozotocin to induce weight gain and decrease blood sugar in diabetic model rats, indicating that 3,4,5-Trihydroxybenzoic acid has a hypoglycemic effect. Its mechanism of action is that gallic acid can reduce the expression of thioredoxin interaction protein, caspase-1, NLRRP3 inflammatory body, and nuclear factor κB in the pancreas tissue of diabetic model rats, and the expression of thioredoxin is up-regulated, inhibiting thioredoxin Mitochondrial oxidative stress damage caused by the combination of protein interaction protein and thioredoxin reduces the islet inflammatory response, thereby inhibiting islet B cell apoptosis
◆ The study found that the minimum inhibitory concentration (MIC) of galla chinensis extract against Shigella flexneri and Staphylococcus aureus were both 2 g / L, and the minimum bactericidal concentration (MBC) was 8 g / L. The MIC value of gallic acid to Staphylococcus aureus biofilm-coated bacteria was 4 g / L, and the MBC value was 32 g / L.
Galla extract series products
Gallic acid, anhydrous
Gallic acid, monohydrate