Yeast Beta D Glucan Instruction
◆ Yeast glucan has recently been listed as a new resource food by the country, which means that the product can be used in more food and related industries. In the near future, everyone will come into contact with or directly or indirectly consume this substance?
◆ β-1,3-D-glucan is a kind of polysaccharide widely existing in microorganisms, mushrooms and plants. It is one of the structural macromolecules that make up the cell walls of higher plants, yeasts and fungi. One of the important sources of β-1,3-D-glucan with strong biological activity is yeast cell wall. Yeast cell walls are composed of three main polysaccharides, including mannoproteins (about 40%), glucan (about 50%) and chitin (about 2%).
◆ Interest in yeast beta glucan began in the 1940s. Dr. Pillemer first discovered and reported that a substance called "Zymosan" in the yeast cell wall can non-specifically stimulate the immune system. In the 1960s, Dr. Nicholas DiLuzio of Tulane University confirmed that the biologically active substance in Zymosan is β-1,3-D-glucan and isolated this substance from baker's yeast. In recent years, a large number of studies have shown that yeast glucan can stimulate the activity of macrophages by binding to special receptors on macrophages, thereby enhancing non-specific immune functions to achieve anti-tumor, anti-inflammatory, and promoting wound healing functions.
Specification of Yeast beta d glucan 70.0%
Loss on drying
Assay (On dry basis)
USP <231>, method II
AOAC 986.15, 18th
AOAC 986.15, 18th
Total Plate Count
◆ Enhance immunity
Unlike other food ingredients, oral glucan is not directly hydrolyzed by acids or enzymes in the stomach and intestines and enters the small intestine directly. Macrophages on small intestinal mucus cells take up glucans through glucan receptors and activate these cells. β-1,3-D-glucan works by stimulating macrophages, which are white blood cells that can play a broad role in protecting and strengthening the immune system, protecting the body from harm.
The antitumor effect of glucan is the result of stimulating the immune system, rather than directly cytotoxic to tumor cells. The advantage of this effect over traditional therapies is that immune cells have the ability to recognize and destroy "bad" cells and "foreign invaders," so glucan does little harm to healthy tissues and cells. At present, the main goal of studying anti-cancer function is to enhance the activity and phagocytosis of macrophages in higher mammalian tissues. This is one of the functions of yeast glucan. In 1981, the Norwegian Cancer Research Center and the Uppsala University of Sweden compared the immunity of 42 natural polysaccharides and found that glucan extracted from yeast and fungi can increase the phagocytic capacity of macrophages in mice by more than 10 times. In the study, the immune effect of other mammals, including humans, has the same result.
◆ Anti-infection, improve disease resistance
Since the 1980s, Harvard research has shown that β-1,3-D-glucan can help people resist a variety of pathogens, such as Staphylococcus aureus, E. coli, Candida albicans, Listeria, Pneumocystis carinii, Leishmania, and roundworms. Researchers have also conducted studies on the anti-infection of glucan in different animals, such as mice, rats, guinea pigs, pigs, etc., which have demonstrated their ability to enhance the body's immunity and improve the status of infection.
Yeast β-glucan can significantly increase the efficacy of antibiotics. When used in combination with antibiotics, its effect on stimulating macrophages can enhance the therapeutic effect of the drug. Experiments on rat peritonitis confirmed that rats with β-1,3-D-glucan alone had a survival rate of 80% (control group survival rate was 20%), and the antibiotic group alone survival rate was 65%. , And the combination has a 100% survival rate.
◆ Radiation resistance
Studies by the United States Air Force Institute of Radiation Biology have shown that yeast beta glucan has a very good effect on the recovery and rapid improvement of immune system resistance after radiation. After a lethal dose of radiation was administered, all mice in the control group died after two weeks, compared with only 40% of the mice in the yeast glucan group. Treating the irradiated mice with β-1,3-D-glucan can enhance the recovery ability of the mice, increase the bone marrow vitality, increase the number of white blood cells, and increase the number of spleen cells.
Yeast Beta D Glucan Application
◆ Animal breeding and feed industry
Yeast bate-glucan is a very good natural immune enhancer. It can provide non-specific and specific immune effects to the body. This is an important way to improve the health of animals. Therefore, it is widely used in the field of animal breeding. Selvaraj and other studies have shown that intraperitoneal injection of yeast glucan into carp can significantly improve its immune function. Courie et al. Used it as an antibiotic substitute in livestock and poultry diets such as pigs and chickens, which can significantly improve the immune function of animals, promote growth, and improve feed conversion and utilization.
At present, the European Union has banned the use of antibiotics, and the problem of antibiotic residues has attracted worldwide attention. This ingredient is the best alternative to antibiotics at present. It has been widely used in the United States, Brazil, and Taiwan in China, and has played a good role in preventing and curing diseases in livestock and poultry and aquatic product breeding, improving feed conversion and greatly reducing animal mortality.
◆ Food industry
This ingredient has high viscosity, water-holding and emulsifying stability. It is often used as a thickener, water-holding agent and emulsifying stabilizer in food industry for foods such as seasonings and desserts. Because beta-glucan is difficult to degrade and consume in the human digestive tract, it can also be used as a low-calorie food additive to provide a fat-like mouthfeel. Studies by Wang Miao and others have shown that using it to replace fat in meat products can not only provide smooth and rich mouthfeel for low-fat meat products, but also improve texture characteristics such as crispness and hardness of meat products. Thammakiti uses it as an emulsifying stabilizer in mayonnaise, which can not only effectively maintain the emulsification stability of mayonnaise, but also strengthen the role of cellulose to prevent lipid absorption, promote the excretion of cholesterol, and increase intestinal motility. Therefore, this powder can be used as a dietary fiber and a high-quality health food additive in the food industry.
◆ Cosmetics industry
Yeast Beta D Glucan can be applied to shampoos, shower gels, sunscreens, and facial masks to exert its anti-infective, anti-radiation, and immune-enhancing effects, thereby protecting the skin from external aggressions. Examples, but have not been reported in the country.