Milk Thistle Extract Coa Instruction
◆ Silybum marianum (L.) Gaertn belongs to the Asteraceae family (Compositae). It is native to southern Europe, southern Russia, Asia Minor and North Africa. Milk Thistle has been used in Europe as a remedy for liver problems for thousands of years. The seeds were consumed by European wet nurses to insure a healthy milk supply. The heads of this Thistle formerly were eaten, boiled, treated like those of the Artichoke.
◆ Silymarin is a flavonoid compound in Silybum marianum extract, which can be used to treat liver, spleen and other diseases. It is the most medicinal part of silybum, mainly including silybin, silydian-in, silychristin and other active ingredients, while silybin It is the main active ingredient in silymarin, accounting for about 60% of it.
◆ Currently, medicinal silybin is a semi-purified silymarin, which is mainly a mixture of enantiomers silybin A and silybin B. It has the functions of scavenging free radicals, resisting lipid peroxidation, protecting liver cells, It can promote the regeneration of liver cells, anti-liver fibrosis, anti-tumor, hypolipidemic and other drug effects, especially in the treatment of liver diseases. In addition, silymarin has estrogen signal regulators, insulin sensitizers, and drug intracellular transport regulators.
Specification of Milk thistle extract 80.0%UV Silymarin
Light yellow-brown fine powder
Odor & Taste
Water & Ethanol
Soluble in ethanol
Loss on drying
Assay(On dry basis)
≥30.0% Silybin + Isosilybin
Total Plate Count
FDA(BAM)Chapter 5,8th Ed
Milk Thistle Extract Coa Benefits
◆ It is widely used in drug, health products, food and cosmetics.
◆ It has the functions of protecting liver cell membrane and improving the liver function.
◆ It has the function of detoxification, reducing the blood fat, benefiting the gallbladder, prot.
◆ It has the function of radiation hardening, arteriosclerosis preventing, and skin-aging delaying. removing the free radical of body.
◆ Milk thistle extract can be applied in food field, it is added into kinds of beverage, liquor and foods as functional food additive.
◆ Marian thistle extract also can be applied in health product field, it is widely added into various kinds of health products to prevent chronic diseases or relief symptom of climacteric syndrome.
◆ Silybum marianum extract powder in cosmetics field, it is widely added into the cosmetics with the function of delaying aging and compacting skin, thus make skin much smooth and delicate.
◆ It can be applied in pharmaceutical field, it is widely added into the medicine which can be used in treating chronic diseases such as cardio-cerebrovascular disease, kidney disease, diabetes mellitus.
Side Effects and Cautions
◆ In clinical trials, Milk Thistle Extract Coa appears to be well tolerated in recommended doses. Occasionally, people report various gastrointestinal side effects.
◆ Milk thistle can produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold,and daisy).
◆ Milk thistle may lower blood sugar levels. People with diabetes or hypoglycemia, or people taking drugs or supplements that affect blood sugar levels, should use caution.
◆ Tell all your health care providers about any complementary health practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.
◆ There is no nationally standardized milk thistle supplement dosing at this time, but most people do best consuming between 20–300 milligrams daily.
Flow chart of ginkgo biloba dry extract