Cardiovascular protection effect of Genistein

- Nov 05, 2019-

Genistein (GEN), chemical name is 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4',5,7-three Hydroxyisoflavones, mainly derived from the extracts of legumes such as genistein (blossom) and broad bean root, are a natural tyrosine kinase and soybean metabolite with anti-tumor and neuroprotective properties. It regulates bone metabolism and lipid metabolism, anti-fibrosis, cardiovascular protection and antioxidant effects.

1. Anti-arrhythmia effect

Studies have shown that genistein can inhibit myocardial ischemia-reperfusion injury arrhythmia caused by left coronary artery ligation, and dose-dependently reverse the arsenic trioxide-induced QT interval prolongation syndrome.

2. Myocardial protection

2. 1 myocardial ischemia protection

Genistein can increase the tolerance of the heart of ovariectomized rats to ischemia and hypoxia. It can protect the isolated heart from ischemia-reperfusion injury by dilating coronary artery, slowing heart rate and enhancing myocardial contractility.

2. 2 Anti-cardiac hypertrophy

Genistein inhibits oxidative stress, regulates the balance of vasoactive substances, inhibits cardiac fibrosis, and slows the progression of cardiac hypertrophy and heart failure in many ways, and protects the heart.

3 Anti-atherosclerosis

3. 1 Regulate lipid metabolism

After feeding the feed containing different concentrations of Genistein, it was found that the serum antioxidant index of hamsters increased significantly, the LDL peroxidation product conjugated diene, thiobarbituric acid reaction substrate decreased significantly, and the vitamin E content in LDL was also higher. .

3. 2 Vasodilation

Genistein can alleviate the inhibition of paraoxon on acetylcholine-induced endothelium-dependent relaxation and has a dose effect.

3. 3 Protective effect on vascular endothelial injury

The protective effect of Gen on Iso-induced HUVEC injury can be achieved by decreasing the levels of VCAM-1, ICAM-1 and E-selectin, increasing the activity of SOD and GSH-Px, and increasing the scavenging of oxygen free radicals.

3. 4 Protection of vascular smooth muscle

◆ Genistein inhibits the proliferation of vascular smooth muscle cells (VSMCs) induced by various factors. Genistein can inhibit the proliferation of human aorticsmooth muscle cells (HASMCs) induced by TNF-α by initiating apoptosis.

◆ In addition, Gen can reduce the incidence of coronary atherosclerosis by reducing the activation of platelets.

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