Efficacy and dosage of Ghana seed extract

- Apr 20, 2020-

◆ Ghana seeds are a source of African bushes and the compound 5-HTP. It has anxiety and appetite-reducing effects. Ghana seeds contain up to 20% by weight of 5-HTP.

5-HTP chemical structure

◆ Ghana seeds are shrubs used in African folk medicine. The seeds are used for aphrodisiac and antibiotic purposes, as well as to treat diarrhea, vomiting, and stomach pain; the leaves are used to treat wounds, and leaf juice is used to treat bladder and kidney diseases. Recently, the plant appears to be used to treat anxiety and depression, insomnia, migraine and headache, and to regulate appetite, leading to weight loss in obese patients; all these effects are considered to be manifestations of the contained 5-HTP, and many supplements are now standardized.

◆ The traditional use of seeds from Ghana is mainly for neurological purposes and is closely related to the known effects of 5-HTP.

Griffonia simplicifollia extract

◆ The dose of 1-25 mg / kg Ghana seeds (20% 5-HTP) was given to rats 1 hour before the light and dark box test. It was noted that 10 and 25 mg / kg could increase the time of light fragments (indicating anti-anxiety), while 5-25 mg / The kg dose appeared to be anxiolytic in the open field test. The time spent in the light / darkness of 10-25 mg / kg Ghana seeds is similar to the active control of 2 mg / kg diazepam.

◆ An extract of Ghana seed (10.24mg, producing 2.56mg 5-HTP), mixed with Centella asiatica and dandelion, five times a day (40mg 5-HTP in total), 20 overweight or obese women No eating disorder), continued for 4 weeks, noticed an increase in satiety and decreased overeating; when weight loss advice and diet were given, the weight loss effect of the experimental group was improved. It has been noted in other studies that in a similar female population, this spray can increase satiety within 2 months.

◆ Limited human weight loss studies using Ghana seed extract, both studies used oral sprays, but were confused with various herbs (in this case it is difficult to put causality on Ghana seed extract). However, rodent studies using only Ghana seed extract also noted that using 25 mg / kg 20% 5-HTP (equivalent to the human dose of 4 mg / kg Ghana seed extract) did reduce appetite.

Griffonia simplicifollia extract 5-HTP

◆ Further research is needed to determine the optimal human dose of Ghana seed extract. The lowest effect dose for rats is 25 mg / kg, which translates to a human dose of 4 mg / kg Ghana seeds, converted to Ghana seed extract (5-HTP) 0.8 mg / kg.

◆ It is unclear whether Ghana seeds have other biological activities than 5-HTP. The human doses listed above are derived from rodent studies and are not optimal, which is why they differ from the optimal dose of 5-HTP.