Yohimbe, CAS No. 146-48-5, belongs to the alkalodis of indole derivatives. Its molecular formula is C21H26N2O3, chemical name is17 "-hydroxy-yohimban-16α-carboxylic acid methyl ester, also known as quebrachine. , Corynine and aphrodine. Yohimbine has optical isomers, divided into a and mouth type, of which p-type yohimbine L-body. There is also yohimbine.
1.1 Organic solvent extraction
Benzene, chloroform and dichloromethane are commonly used. Because alkaloids are often combined with acids in plants to form salts, the crude drug powder should be mixed with a small amount of alkaline water or ground until wet, so that the alkaloids become free, and then soaked or infiltrated with organic solvents Alas.
1.2 Polar solvent extraction
Commonly used ethanol or 60% to 80% dilute ethanol. By extracting the crude drug powder with yeast or infiltration at room temperature, alkaloids and its salts can be extracted.
1.3 Acid water extraction
The crude drug powder is directly soaked with acid water for infiltration or heating, and then the extract is passed through an ion exchange resin to obtain an alkaloid salt.
2.1 Chemical Synthesis
Since yohimbine was isolated in 1900, drug workers have been studying the chemical structure and properties of yohimbine, and finally determined its three-dimensional configuration in 1943, Its degradation pathway. Ward first synthesized yohimbine chemically in 1958. Since then, yohimbine's synthetic route has been continuously improved. Among them, Szantay and Co-Worker synthesis method, Stork-Darling synthesis method, and Kametani synthesis method have three industrial applications.