Japanese Lentinus edodes mycelium extract for hepatitis treatment

- Jul 03, 2020-

Lentinus edodes mycelium culture medium extract (LEX) is to cultivate the mycelium of Lentinus edodes (Berk.) SING. as a solid medium based on food raw materials. An extract obtained by special physical treatment. Its main components are water-soluble modified lignin, polysaccharides, and protein, in addition to being rich in minerals.


Since 1972, LEM-containing water, solutions and granules have been approved for sale in the Japanese market in accordance with the Food Sanitation Law. As a kind of health food, it circulates on the Japanese market under the trade name of "spine fungus" and "mushroom source".


In June 1981, the Japanese Pharmaceutical Association Hokuriku Branch issued a conclusion: LEM has the effect of inhibiting the formation of liver tumors and the proliferation of transplanted tumors in animal experiments. Regarding the tumor suppressing effect, subsequent studies have also shown that it has inhibitory effects The role of colorectal carcinogenesis, and, recent research results show that it can inhibit liver metastasis of malignant tumors.

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More clinical studies have found that these effects are not the direct effects of LEM on cancer cells, but are the result of host-mediated immune regulation. From the results of nvitro (in vitro) and nvivo (in vivo) , It can be confirmed that LEM will induce the production of 1L-1, TNF-aIL-12, N0, IFN-Y, IL-2.


On the other hand, with regard to human diseases, professional doctors conducted experiments on the effectiveness and safety of viral hepatitis (hepatitis B caused by hepatitis B virus CHBV), and conducted basic research on its immunological effects . After analyzing 106 patients with HBe antigen-positive chronic hepatitis, it was found that the antigen decreased, e antibody increased, DNA-P activity decreased, serum GOT and GPT decreased.

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In addition, regarding side effects, only a few cases of mild digestive organ symptoms were reported, and no serious symptoms were found. In basic research, it was found that it has an inhibitory effect on immune hepatocyte disorders and an enhanced effect on antibody production. In addition, as a model animal of human hepatitis B, it has been administered orally for a long time to the concerned groundhog In the test, it was found that it has an inhibitory effect on the proliferation of woodchuck hepatitis virus and can improve liver dysfunction.