How does L-5-methyltetrahydrofolate Ca (5-MTHF) make its efficacy possible?

- Nov 19, 2019-

◆ Calcium L-5-methyltetrahydrofolate (5-MTHF CA) is a naturally occurring salt-forming methyl derivative of folic acid. L-5 methyltetrahydrofolic acid is also known as L-methylfolate. Folic acid is mainly found in human blood and tissues. L-5-MTHF exists in a way that participates in many biochemical reactions in the human body. L-5-MTHF is the main form of folic acid in the body and can be directly absorbed and utilized by the body without complicated enzymatic reactions.

Calcium L-5-methyltetrahydrofolate-5-MTHF-structure

◆ After being absorbed by the small intestine, folic acid is reduced by coenzyme-reduced nicotinamide adenine dinucleotide (NADPH) and dihydrofolate reductase to obtain dihydrofolate, which is then reduced by reduced coenzyme II and ascorbic acid. Metabolism produces biologically active THF. Finally, THF is methylated in the liver, and methyltetrahydrofolate is finally produced by the human body. The biologically active folic acid of the biochemical pathway involves a series of enzymatic reactions and cofactors. The absorbed folic acid is reduced and methylated to 5-MTHF during intestinal mucosal cell metabolism. Methyl donors are involved in a number of biochemical processes. It also acts as a donor involved in the synthesis of nucleotides and supports the biosynthesis of DNA.


◆ Benefits of L-5-mthf

Lack of folic acid is usually caused by vitamin deficiency, which is insufficient for absorption. During pregnancy and breastfeeding, the need for folic acid is increased during the growth of children. Under the influence of absorption or metabolic changes or drugs, the consumption of folic acid-rich foods cannot guarantee the dose provided, so it needs to be given. supplement.


◆ There are many methods for synthesizing L-5-MTHF at home and abroad, such as catalytic hydrogenation, dihydrofolate reductase, sodium dithionite reduction, and chemical reduction.


L-5-methyltetrahydrofolate dosage and uses

The expected conditions for the use of 5-MTHF are consistent with folic acid in quality and quantity, and the European Food Safety Authority (2004) has determined the highest tolerable level of tolerance, 1 mg per day for adults.


In this maximum tolerable intake, calcium intake reaches 0.08 mg per day for adults.