Lutein supplementation for diabetic macular edema

- Jun 18, 2020-

Lutein is a natural component of the retina and can be obtained from the diet. Due to protein glycosylation and activation of the polyol pathway, oxidative stress is significantly increased in diabetic patients. As a result, it develops into diabetic retinopathy and even macular edema, causing severe visual impairment and even blindness. Patients with macular edema obviously lack lutein, so additional lutein intake is required to prevent and reduce complications.


Carotenoids and their properties Carotenoids are natural compounds found in different plants, and are commonly found in various animals, algae, fungi and bacteria. Fundamentally, these compounds are considered necessary for life, and their function is related to plant photosynthesis (obtaining photopigments, photoprotection).There are two types of carotenoids: carotenes, of which the carotenoids do not contain oxygen (eg Such as: β-carotene, lycopene), and the end ring of lutein contains oxygen (for example: lutein and zeaxanthin). These four carotenes are the most abundant in human blood.However, it was found that the largest proportion in plasma is lutein, in which macular pigment (central area of the retina and largest eye vision) accounts for 90%.Carotenoid is a non-saponified monolipid isoprene, which has more conjugated double bonds, the main advantage is the absorption of ultraviolet light, its importance is beneficial to visual function.90% of the macular pigment corresponds to lutein, and the remaining 10% zeaxanthin and mesozeaxanthin.

Currently, lutein is used to prevent age-related macular degeneration, and it has been shown to have a curative effect in reducing diabetic macular edema. Hu Bojie et al. used interventions on 30 patients to confirm that they can alleviate non-proliferative diabetic retinopathy in patients.

Let them take 6 mg of lutein and 0.5 mg of zeaxanthin orally for three months, and compare it with the second non-lutein-treated group. The control group showed that healthy people did not develop diabetic retinopathy. It showed that 83% of patients had reduced foveal thickness after drug treatment.

This supplement is an excellent treatment option for individuals with diabetic macular edema.