What does the proportion of lutein and zeaxanthin have the best synergistic antioxidant activity?

- Sep 22, 2019-

Lutein and zeaxanthin are the main carotenoids in human eyes and they play an important role in the prevention of eye diseases. The synergistic antioxidant effect of lutein and zeaxanthin in the ratio of 1:2 was the best.

◆ Carotenoids are a class of compounds having a plurality of conjugated double-bonded decene groups, and more than 700 carotenoids have been discovered to date. Epidemiological investigation, animal in vivo experiments and results of cell experiments, carotenoids have strong anti-cancer, anti-radiation and prevent cardiovascular diseases. These protective effects of carotenoids are directly or indirectly related to their antioxidant effects. Some carotenoids play important roles in human tissues and organs, such as lutein and zeaxanthin, which are components of the macula. Clinical studies have found that lutein intake can increase the pigment content of the macula, and can improve the vision of patients with age-related macular degeneration (AMD). Because lutein can scavenge free radicals and absorb blue light, it can prevent cataracts and prevent cataracts. Eye damage, while lutein and zeaxanthin are present in a suitable ratio, which has a better protective effect on vision.

◆ In addition to many light-sensitive compounds, the retina contains an easily oxidizable substrate such as DHA. The photosensitive substance on the retina will undergo an oxidation reaction in the presence of light stimulation, resulting in a pair Retinal pigment epithelial cells are toxic substances, and this substance is one of the main factors in the occurrence of age-related macular degeneration. In addition, a large number of capillaries are distributed in the retina, which makes the oxygen concentration high. The lens focus can produce high-intensity, high-energy light, and light can easily induce singlet oxygen free radicals in the retina that react with double-bonded molecules (such as DHA), which can further trigger the retina Oxidative damage to lipid peroxidation chain reaction. Lutein and zeaxanthin are components of the macula of the retina. 

Lutein and zeaxanthin are structurally identical to each other, differing only in the position of the double bond of one of the ionone rings. This double bond of lutein forms an allyl hydroxyl end, and the corresponding double bond in zeaxanthin forms a conjugated system with an adjacent linear double bond. In terms of antioxidant activity, the effects of the two in different antioxidant indexes are different, which may be related to the different roles of the active groups and the double bond positions in the oxidation process. After mixing in different proportions, it still showed different antioxidant effects, indicating that the antioxidant synergistic effect of lutein and zeaxanthin has a great relationship with its ratio. The study found that: lutein and zeaxanthin can play a better synergistic antioxidant effect in a ratio of 1:2, and have higher DPPH free radical scavenging ability, iron ion reducing ability and oxygen radical absorption capacity. In vivo experiments, lutein/zeaxanthin 1:2 group showed better antioxidant effect.

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