Astaxanthin is a natural carotenoid found in microalgae and certain seafood. After 28 preclinical trials and 5 human trials conducted by Washington State University, researchers led by Dr. Boon Chew concluded that among various biomarkers, first in test tubes, then in animals, and finally in humans Research participants have seen that astaxanthin has a significant regulatory effect on the body's immunity.
The authors of the study said that astaxanthin has the effect of regulating immune response, inhibiting the growth of cancer cells, reducing bacterial load and gastric inflammation, and protecting rabbits from oxidative stress in vitro and in rodent models. This study is the first to assess whether the human body has any form of immune system regulation after astaxanthin intake.
All participants in this study were young, healthy and slim women, with an average age of 21.5 years. In an 8-week double-blind, placebo-controlled study, participants received 2 mg, 8 ng, or placebo doses each day for 8 consecutive weeks. The immune response test was conducted at 0, 4, and 8 weeks, and the tuberculin test was conducted at the end of 8 weeks.
The researchers used reversed-phase high-performance liquid chromatography (HPLC) to determine the content of astaxanthin in the plasma. In addition, the proliferation of peripheral blood mononuclear cells in the blood (these cells can kill cytotoxic activity), tuberculin delayed hypersensitivity, cytokine production, C-reactive protein, oxidative damage to DNA, and lipids are also evaluated Peroxide and other situations.
The researchers said that in previous studies, astaxanthin was a free radical antioxidant that was several times more active than β-carotene and a-tocopherol. Astaxanthin in the diet can enhance the cell-mediated and humoral immune responses of young healthy women. All these immune responses are usually observed after subcutaneous injection of tuberculin and supplemented with astaxanthin for 8 weeks.
Astaxanthin can also enhance the cytotoxic activity of natural killer cells. Natural killer cells have the ability to monitor tumors and virus-infected cells. Therefore, astaxanthin may play a potential role in the etiology of cancer. After astaxanthin supplementation, T cell and B cell subsets were higher. These cells are involved in immune regulation and antiviral activity, respectively. Skin tuberculin test also showed increased expression of leukocyte functional antigen LFA-1.In the fourth week of supplementation, astaxanthin significantly reduced the biomarkers of DNA damage. The maximum response can be observed even if a low dose of 2 mg is ingested. The 2 mg dose is also the best dose to reduce the concentration of plasma C-reactive protein, which proves its anti-inflammatory effect on the human body.