What is the clinical use of Rhodiola rosea extract ingredients?

- Sep 10, 2019-

Rhodiola is a sedum species plant with a wide variety of clinical applications and a long history. There are also differences in the clinical efficacy of Rhodiola planted in different regions and climates.

 

1. Main ingredient

In recent years, there have been many studies on the pharmacology of Sedum plants at home and abroad. More than 40 kinds of chemical components have been isolated and extracted from various Sedum plants. Among them, salidroside and rosavin, as the most important pharmacological active ingredients, and it has anti-inflammatory, Regulate immunity, anti-fatigue, delay aging, blood pressure and other effects. The determination of the content of active ingredients has gradually occupied the dominant position in the quality evaluation of traditional Chinese medicine. The quality evaluation of Rhodiola is mainly based on the content of main components such as salidroside and polysaccharide. A research group tested four different varieties of Rhodiola active ingredients. The highest content of salidroside was Qinghai Rhodiola, followed by Rhodiola, and the lowest content was Rhodiola and Rhodiola. . The content of polysaccharides in 13 kinds of Rhodiola rosea produced in the western Sichuan Plateau was detected, and the highest was Wolong Rhodiola and Rhizoma Rhodiola. The content of Rhodiola rosea was the least. Although they are of the same genus, the chemical components and content of Rhodiola in different habitats are significantly different, and the diversity of biological activity lays a foundation for the wide application of Rhodiola in clinical practice.

 

2 Botanical studies

2.1 Type and distribution

There are nearly 100 species of Rhodiola in the world. There are 73 species of Sedum in China, and plant resources are concentrated in the southwest and northwest regions. The most diverse areas are Tibet and Sichuan. 26 species of Sedum plants were found in the western Sichuan Plateau, accounting for 1/3 of the total species of Sedum. Twenty-one wild sedum plants were found in Diqing, Yunnan. The Tibetan medicine Rhodiola resources are widely distributed, and their different growing environments make their varieties different. Rhodiola rosea is beneficial to qi and blood circulation, Tongmai Pingchuan; narrow leaf Rhodiola sinensis heat detoxification, swelling, used to treat plague, lung heat, pulse heat, colds and swelling of the limbs.

 

2 clinical application

2.1 Heart disease

2.1.1 Acute myocardial infarction

With the deepening of clinical research on Rhodiola, more and more indicators have been found to support the clinical efficacy evaluation of Rhodiola. The study found that Dazhuhongjingtian injection can effectively reduce myocardial infarct size in rats with acute myocardial infarction, significantly improve inflammatory cell infiltration in myocardial infarction area, decrease plasma cardiac troponin CTNI level and plasma myocardial enzyme CK and LDH activity. Clinical studies have found that the addition of Rhodiola injection in the treatment of myocardial infarction can significantly reduce the concentration of C-reactive protein and BNP in patients with conventional Western medicine.

 

2.1.2 Angina pectoris

Coronary vascular stenosis and increased arterial pressure are the main causes of angina pectoris. Rhodiola can not only dilate blood vessels, increase blood flow, but also reduce arterial pressure, reduce total peripheral resistance, and effectively reduce cardiac afterload, and relieve angina pectoris without significantly increasing myocardial contractility and left ventricular pressure. The cause of seizures, the heart function is improved, Rhodiola can not only play a role in the cause of angina, but also in the repair of damaged cardiomyocytes.

 

2.1.3 Heart failure

Modern pharmacological studies have shown that the main chemical constituents of Rhodiola rosea L. and its compounds such as glycosides, flavonoids and phenylpropanoids can enhance the body's ability to resist hypoxia, reduce the body's oxygen consumption, and significantly dilate coronary vessels. Increase blood flow and reduce heart afterload.

 

2.1.4 Arrhythmia

Calcium chloride induces ventricular arrhythmias. The mechanism by which Rhodiola can significantly reduce the concentration of calcium chloride may be to stabilize cell membrane ion pump and calcium channel, stabilize cell membrane reactivity, slow down the abnormal increase of calcium ion influx, and inhibit or eliminate ectopic rhythm.

 

2.2 Brain diseases

Hyperviscosity and platelet aggregation are risk factors for acute ischemic stroke. Modern pharmacological studies have shown that Rhodiola can effectively reduce whole blood viscosity, reduce red blood cell rigidity index and aggregation index, significantly reduce hematocrit and fibrinogen, thereby inhibiting platelet aggregation, improving blood rheology, preventing and treating acute deficiency. Bloody stroke.

 

2.3 Anti-aging

Free radical theory is the classic theory of aging. Oxygen free radical reaction and lipid peroxidation play an important role in the metabolism of the body. Studies have shown that salidroside is the main natural antioxidant in Rhodiola.

 

2.4 Altitude reaction

Acute altitude sickness (AMS) is highly damaging if not treated in time. According to the report, the incidence of AMS by unaccompanied personnel by plane to 3600m is 20%~50%, and AMS has been widely accepted. Studies have found that the expression of hypoxia-inducible factor-1 (messeng ribonucleic acid) in cardiomyocytes may be one of the causes of hypoxia in the plateau. Rhodiola can regulate its expression and become one of the methods to treat hypoxia in the plateau.



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